-Ddefer_builds_mode-setting → set defer_builds_mode in order to defer generation of geometries until they are needed. This setting is can improve performance when loading long dynamics trajectories or thousands of small-molecule structures.
-o → disable security protections – CAREFUL! ONLY USE WHEN OPENING TRUSTED CONTENT.
-Osphere_mode-setting → show the molecule as spheres and set sphere_mode in order to potentially reduce the complexity of the sphere representation.
pymol -O 1 huge_file.pdb
can be used to load and display systems with millions of atoms.